Stereoselective Synthesis of Highly Functionalized Trifluoromethylated Cyclobutenes

Abstract

1,1,1-Trifluoro-4-arylbutan-2,4-diones undergo a smooth reaction with dialkyl acetylenedicarboxylates and triphenylphosphine to produce phosphorus ylide intermediates, which undergo stereoselective intramolecular Wittig reaction to produce dialkyl 4-arylcarbonyl-3-trifluoromethyl-cyclobut-2-ene-1,2-dicarboxylates in good yields.

Key words

intramolecular Wittig reaction - trifluoromethylated cyclobutenes - ylide chemistry

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