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Synthesis 2004(15): 2441-2444  
DOI: 10.1055/s-2004-831233
PAPER
© Georg Thieme Verlag Stuttgart · New York

Simple, Efficient and One-Pot Method for Synthesis of Aminomethylene gem-Diphosphonic Acid Derivatives from Ketones via Beckmann Rearrangement

Mingshu Wu, Ruyu Chen*, You Huang*
Institute and National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China
Fax: +86(22)23503438; e-Mail: wums@eyou.com;
Further Information

Publication History

Received 1 March 2004
Publication Date:
22 September 2004 (online)

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Abstract

A simple, expeditious and convenient synthesis of aminomethylene gem-diphosphonic acid derivatives in one-pot reaction using ketones, hydroxylamine hydrochloride, phosphorus trichloride and water as starting materials in the presence of pyridine via Beckmann rearrangement is described in the modest yields.

Key words

aminomethylene gem-diphosphonic acid derivatives - ketones - Beckmann rearrangement - hydroxylamine hydrochloride - phosphorus trichloride

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