Synthesis, Table of Contents PAPER © Georg Thieme Verlag Stuttgart · New York Asymmetric Synthesis of 3-Substituted Dihydro-2H-isoquinolin-1-ones, Dihydro- and Tetrahydroisoquinolines via 1,2-Addition/Ring Closure Dieter Enders*, Volker Braig, Marine Boudou, Gerhard RaabeInstitut für Organische Chemie, Rheinisch-Westfälische Technische Hochschule, Professor-Pirlet-Straße 1, 52 074 Aachen, GermanyFax: +49(241)8092127; e-Mail: Enders@rwth-aachen.de; Recommend Article Abstract Buy Article All articles of this category Abstract The asymmetric synthesis of 3-substituted dihydro-2H-isoquinolin-1-ones, dihydro- and tetrahydroisoquinolines is described. The key operation is a tandem 1,2-addition/ring closure sequence employing lithiated ortho-toluamides and aldehyde SAMP- or RAMP-hydrazones as substrates, followed by N-N bond cleavage to remove the auxiliary. Moderate to good yields and high enantiomeric excesses (ee = 85-99%) are reached. 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