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Horm Metab Res 2005; 37(5): 316-325
DOI: 10.1055/s-2005-861487
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Soy Protein Influences the Development of the Metabolic Syndrome in Male Obese ZDFxSHHF Rats

J.  Davis1, 2 , M.  J.  Iqbal1 , J.  Steinle2 , J.  Oitker2 , D.  A.  Higginbotham1, 2 , R.  G.  Peterson3 , W.  J.  Banz1, 2
  • 1 Department of Animal Science, Food & Nutrition, Southern Illinois University, Carbondale, IL, USA
  • 2 Department of Physiology, Southern Illinois University, Carbondale, IL, USA
  • 3 Indiana University School of Medicine, Indianapolis, IN, USA
Further Information

Publication History

Received 18 October 2004

Accepted after revision 20 December 2004

Publication Date:
22 June 2005 (online)

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Abstract

Previous investigations have demonstrated a marked effect of soy protein on the metabolic syndrome (MS). The purpose of this preliminary study was to identify the effects of soy-based diets on male obese ZDFxSHHF (fa/fa-cp/?) rats. Animals were randomly assigned to one of four diets: control, casein (C); low-isoflavone (LIS) soy protein; high-isoflavone (HIS) soy protein; or casein + rosiglitazone (CR). Physiological, biochemical, and molecular parameters were determined at sacrifice. Body weight (p < 0.01) and food intake (p < 0.05) were lower in LIS-fed rodents. Rosiglitazone-treated animals had higher body weight and adiposity (p < 0.05). LIS and CR groups exhibited better glycemic control (p < 0.05), but with a limited effect in rosiglitazone-treated animals. HIS fed rats had higher glucose and triacylglyceride levels (p < 0.01), and lower plasma insulin (p < 0.01). Renal function parameters with the exception of an increase in systolic blood pressure (p < 0.05) were all suppressed in the LIS group (p < 0.01). The CR group had twofold PPARα and PPARγ mRNA abundance (p < 0.01). LIS-fed animals also exhibited greater abundance of PPARγ mRNA (p < 0.001), and nearly threefold FAS and CPT-1 mRNA levels (p < 0.05). HIS-fed rats also had higher abundance of CPT-1 mRNA, as well as a lower abundance of ACC mRNA (p < 0.05). Soy-based diets, influenced by isoflavone content and distinct from rosiglitazone, improved several metabolic parameters in obese ZDFxSHHF rats.

Key words

Soy protein - Isoflavone content - Metabolic syndrome - Gene expression - ZDFxSHHF

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William J. Banz, Ph. D., RD

Department of Animal Science, Food and Nutrition

Southern Illinois University · Carbondale · IL 62901-4317 · USA

Phone: +1 (618) 453 75 11

Fax: +1 (618) 453-75 17

Email: banz@siu.edu