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Synthesis 2005(12): 1935-1938  
DOI: 10.1055/s-2005-869898
PAPER
© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis of 3-Benzoyl- and 3-Acetyl-1,2,4-Oxadiazole Derivatives Using Iron(III) Nitrate

Ken-ichi Itoh*a, Hiroshi Sakamakia, C. Akira Horiuchib
a College of Science and Technology, Nihon University, 7-24-1 Narashinodai, Funabashi-shi, Chiba 274-8501, Japan
Fax: +81(80)474695477; e-Mail: k-itoh@chem.ge.cst.nihon-u.ac.jp;
b Department of Chemistry, Rikkyo (St. Paul’s) University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan
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Publication History

Received 13 January 2005
Publication Date:
18 May 2005 (online)

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Abstract

The reaction of nitriles and acetophenone with iron(III) nitrate at 80 °C gave the corresponding 3-benzoyl-1,2,4-oxadiazole derivatives. Moreover, in this reaction using acetone, the 3-acetyl-1,2,4-oxadiazole derivatives were obtained.

Key words

ketones - nitriles - heterocycles - iron(III) nitrate - 1,2,4-oxadiazole derivatives