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Synthesis 2005(11): 1748-1750
DOI: 10.1055/s-2005-869899
DOI: 10.1055/s-2005-869899
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones under Solvent-Free Conditions
Further Information
Received
4 January 2005
Publication Date:
18 May 2005 (online)
Publication History
Publication Date:
18 May 2005 (online)
Abstract
Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.
Key words
pyrimidinones - ruthenium - aldehyde - Biginelli reaction - solvent-free conditions - heterocycles
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