Fluorination of Ketones Using Iodotoluene Difluoride

Abstract

Fluorination of ketones was achieved by the reaction of silyl enol ethers with iodotoluene difluoride in the presence of BF₃·OEt₂ and a Et₃N·HF complex.

Key words

fluorination - iodotoluene difluoride - silyl enol ether - ketone - hypervalent iodine

References

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19

An equilibrium between two isomers of 7 was not observed under the reaction conditions.

21

A centrifuge tube with a screw cap made of Teflon FEP, a copolymer of TFE and hexafluoropropylene, was used.