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Synthesis 2005(15): 2497-2502
DOI: 10.1055/s-2005-872116
DOI: 10.1055/s-2005-872116
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of 1,2,3-Triazoles by Cycloadditions of Azides with Enol Ethers
Further Information
Received
24 December 2004
Publication Date:
04 August 2005 (online)
Publication History
Publication Date:
04 August 2005 (online)
Abstract
1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.
Key words
azides - cycloadditions - heterocycles - nitrogen - regioselectivity
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