Expedited Synthesis of Substituted Dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones Structurally Related to Granulatimide

Abstract

Dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones can be considered as granulatimide analogues. In view of structure-activity relationship studies in these series, a parallel liquid-phase microwave-assisted synthesis was developed to generate a small library of compounds bearing various substituents at positions 8, 9, 10, or 11 on the aromatic framework.

Key words

parallel synthesis - granulatimide - antitumor agents - dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraone

References

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19

For SPE purifications, Waters Oasis HLB extraction cartridges (6 g) were used with the following eluents: H₂O, then H₂O-MeCN (80:20), and then MeCN. For some compounds a gradient performed with Jones Flash master II was necessary. After evaporation, Et₂O was added to the solid residues, the compounds were filtered and dried.