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Semin intervent Radiol 2006; 23(1): 064-072
DOI: 10.1055/s-2006-939842
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Yttrium-90 Radioembolization of Hepatocellular Carcinoma and Metastatic Disease to the Liver

Robert J. Lewandowski1 , Riad Salem1
  • 1Department of Radiology, Division of Interventional Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern Memorial Hospital, Chicago, Illinois
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Publikationsdatum:
04. April 2006 (online)

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ABSTRACT

Yttrium-90 (90Y) radioembolization is a catheter-based therapy that delivers internal radiation to hepatic tumors in the form of microspheres. 90Y can be delivered to the hepatic tumor as either a constituent of a glass microsphere, TheraSphere®, or as a biocompatible resin-based microsphere, SIR-Spheres®. Once embedded within the tumor microcirculation, these microspheres emit β-radiation at therapeutic levels. While the technical aspects of radioembolization are quite complex, the collective clinical experience presented in the literature supports the use of 90Y radioembolization for unresectable hepatic malignancies.

KEYWORDS

TheraSphere® - SIR-Sphere® - radioembolization - yttrium-90 - hepatocellular carcinoma - metastatic disease to the liver - liver cancer - liver tumor

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Riad SalemM.D. 

Director of Interventional Oncology, Robert H. Lurie Comprehensive Cancer Center

676 N. St. Claire, Suite 800, Chicago, Illinois 60611