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Synthesis 2006(15): 2573-2579  
DOI: 10.1055/s-2006-942439
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of New, Paramagnetically Modified Heterocycles

Tamás Kálaia, Balázs Bognára, József Jekőb,c, Kálmán Hideg*a
a Department of Organic and Medicinal Chemistry, University of Pécs, 7602 Pécs, P.O. Box 99, Hungary
Fax: +36(72)536219; e-Mail: kalman.hideg@aok.pte.hu;
b ICN Hungary, 4440 Tiszavasvári, P.O. Box 1, Hungary
c Department of Chemistry, College of Nyíregyháza, 4440 Nyíregyháza, Sóstói st. 31/B, Hungary
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Publication History

Received 14 March 2006
Publication Date:
28 June 2006 (online)

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Abstract

Starting from readily available paramagnetic five- and six-membered ketones and pyrroline aldehyde, a range of spin labeled heterocycles such as benzazoles, pyrrole, oxazole, quinoline, benzofuran, thiadiazole have been synthesized in both ‘classical’ and Pd-catalyzed reactions. These methods were used in the synthesis of paramagnetic ligands such as oxin and porphyrin.

Key words

free radicals - heterocycles - ketones - ligands - palladium