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Planta Med 2006; 72(12): 1132-1135
DOI: 10.1055/s-2006-947239
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Antimycobacterial Activity of Geranylated Furocoumarins from Tetradium daniellii

Michael Adams1 , Sabine Ettl1 , Olaf Kunert2 , Abraham Abebe Wube1 , Ernst Haslinger2 , Franz Bucar1 , Rudolf Bauer1
  • 1Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria
  • 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Graz, Austria
In memory of Professor Ernst Reinhard
Further Information

Publication History

Received: April 18, 2006

Accepted: July 6, 2006

Publication Date:
18 September 2006 (online)

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Abstract

Seven geranylated furocoumarins were isolated from the fruits of Tetradium daniellii (Benn.) T.G. Hartley (Rutaceae) and tested for their antimycobacterial activity against Mycobacterium fortuitum, M. smegmatis and M. phlei. They were shown to be highly active, with minimal inhibitory concentrations (MICs) ranging from 8 to 64 μg/mL. Xanthotoxin and xanthotoxol, representing furocoumarins lacking the lipophilic geranyl side chain, were tested similarly and were shown to be inactive. Geraniol alone was inactive as well. The antimycobacterial activity of the substances was dependent on the position and polarity of the geranyl moiety. The compounds were purified using chromatographic methods. Structure elucidation was achieved with 1D and 2D NMR experiments.

Key words

Tetradium daniellii - Rutaceae - geranylated furocoumarins - antimycobacterial

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Prof. Dr. Rudolf Bauer

Institute of Pharmaceutical Sciences

Department of Pharmacognosy

University of Graz

Universitätsplatz 4

8010 Graz

Austria

Phone: +43-316-380-8700

Fax: +43-316-380-9860

Email: rudolf.bauer@uni-graz.at