First Example of Lewis Acid Catalyzed 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Formation

Abstract

A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) trif­late shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter reaction times, higher conversion, and better purity profiles as compared to the traditional uncatalyzed reactions.

Key words

Lewis acids - catalysis - heterocycles - indium - condensation

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