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Planta Med 1998; 64(3): 208-211
DOI: 10.1055/s-2006-957410
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of Labdane Type Diterpenes Against Human Leukemic Cell Lines in vitro

Kostas Dimas1 , Costas Demetzos2 , Marios Marsellos3 , Roula Sotiriadou1 , Mixalis Malamas3 , Dimitrios Kokkinopoulos1
  • 1Hellenic Anticancer Institute, Dept. of Immunology, Athens, Greece
  • 2Laboratory of Pharmacognosy, School of Pharmacy, University Campus, Athens, Greece
  • 3Department of Pharmacology, University of loannina Medical School, loannina, Greece
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Nine labdane type diterpenes isolated from the plant Cistus creticus subsp. creticus and from the resin “Ladano” which is excreted on the surface of the leaves and stems of this plant, were examined for their in vitro cytotoxic activity against 14 human leukemic cell lines. Compound 1, (13E)-labd-13-ene-8α,15-diol, exhibited cytotoxic activity against 13 of the cell lines tested, while compound 2, (13E)-labd-7,13-dienol, was active only against HL60 cells. Further compound 1 was examined for its effect on the uptake of [3 H]-thymidine as a marker of DNA synthesis.

Key words

Cistus creticus Cistaceae - labdane diterpenes - Ladano - cytotoxicity - DNA synthesis