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Planta Med 1998; 64(5): 464-466
DOI: 10.1055/s-2006-957485
Letters

© Georg Thieme Verlag Stuttgart · New York

Licochalcone A: An Inducer of Cell Differentiation and Cytotoxic Agent from Pogostemon cabling 1

Eun Jung Park2 , Hae Ran Park2 , Ji Suk Lee2 , Jinwoong Kim2
  • 2College of Pharmacy, Seoul National University, Seoul, Republic of Korea
1 Part 2 in the series “Screening and isolation of the cell differentiation inducers from medicinal plants”. For part 1, See ref.(1)
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1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3′,4′-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and PI-PLCγ1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.