Flavonoids and Lignans from Virola surinamensis Twigs and their in vitro Activity against Trypanosoma cruzi

Norberto Peporine Lopes; Patrícia Chicaro; Massuo Jorge Kato; Sergio Albuquerque; Massayoshi Yoshida

doi:10.1055/s-2006-957548

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Planta Med 1998; 64(7): 667-669
DOI: 10.1055/s-2006-957548

Letter

Flavonoids and Lignans from Virola surinamensis Twigs and their in vitro Activity against Trypanosoma cruzi

Norberto Peporine Lopes¹ ^, ² , Patrícia Chicaro¹ , Massuo Jorge Kato¹ , Sergio Albuquerque² , Massayoshi Yoshida¹ ^, ³

¹Instituto de Química, Universidade de São Paulo, São Paulo-SP, Brazil
²Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP, Brazil
³Instituto de Química, Universidade Estadual Paulista, Araraquara-SP, Brazil

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Publication History

1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

Dichloromethane extracts from twigs of Virola surinamensis (Myristicaceae) showed in vitro trypanosomicidal activity against trypomastigote form of Trypanosoma cruzi. The extract, fractionated by preparative circular chromatography and preparative high-performance liquid chromatography yielded two steroids, two lignans, five flavonoids, and one polyketide. Among the isolated compounds, the lignans presented the highest trypanosomicidal activity.