Polyacetylene Analogs, Isolated from Hairy Roots of Panax ginseng, Inhibit Acyl-CoA : Cholesterol Acyltransferase

Byoung-Mog Kwon; Sook-Hee Ro; Mi-Kyoung Kim; Ji-Youn Nam; Hyun-Ju Jung; Ihn-Rhan Lee; Young-Kook Kim; Song-Hae Bok

doi:10.1055/s-2006-957763

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Planta Med 1997; 63(6): 552-553
DOI: 10.1055/s-2006-957763

Letters

Polyacetylene Analogs, Isolated from Hairy Roots of Panax ginseng, Inhibit Acyl-CoA : Cholesterol Acyltransferase

Byoung-Mog Kwon¹ , Sook-Hee Ro² , Mi-Kyoung Kim¹ , Ji-Youn Nam¹ , Hyun-Ju Jung¹ , Ihn-Rhan Lee² , Young-Kook Kim¹ , Song-Hae Bok¹

¹Protein Regulator RU, Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yoosung, Taejon, Korea 305-600
²Ewha Womans University, College of Pharmacy, Seoul, Korea

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

In the course of our screening program for acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC₅₀ values of 94, 80, 45 and 79 µM, respectively.