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Planta Med 1995; 61(1): 62-65
DOI: 10.1055/s-2006-958001
Paper

© Georg Thieme Verlag Stuttgart · New York

Bio-active Compounds from Psychotria camponutans

Pablo N. Solis1 , Caroline Lang'at1 , Mahabir P. Gupta2 , Geoffrey C. Kirby3 , David C. Warhurst3 , J. David Phillipson1
  • 1Department of Pharmacognosy, The School of Pharmacy, University of London, 29/39 Brunswick Sq., London WC1N 1AX, U.K.
  • 2Centro de Investigaciones Farmacognosticas (CIFLORPAN), Facultad de Farmacia, Universidad de Panama, Apdo 10767, Panama
  • 3Department Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

A new benzoquinone (1-hydroxybenzoisochromanquinone) and benz[g]isoqumoline-5,10-dione have been isolated from the woody parts of Psychotria camponutans, as a result of bioactivity-guided fractionation. The compounds were characterized by UV, IR, EI-mass, 1H-, and 13C-NMR, and HETCOR NMR spectroscopy. Both compounds, together with acetylbenzoisochromanquinone, showed in vitro strong activity against brine shrimp, KB cells, and chloroquine-resistant P. falciparum.

Key words

Psychotria camponutans - Cephaëlis camponutans - Rubiaceae - bio-active compounds - 1-hydroxybenzoisochromanquinone - benzo[g]isoquinoline-5,10-dione - benzoquinone - brine shrimp - KB cells - Plasmodium falciparum