A Diterpene from Mikania obtusata Active on Trypanosoma cruzi

Tânia M. A. Alves; Patrícia P. G. Chaves; Luiz M. S. T. Santos; Tanus J. Nagem; Silvane M. F. Murta; Isabela P. Ceravolo; Alvaro J. Romanha; Carlos L. Zani

doi:10.1055/s-2006-958011

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Planta Med 1995; 61(1): 85-87
DOI: 10.1055/s-2006-958011

Letter

A Diterpene from Mikania obtusata Active on Trypanosoma cruzi

Tânia M. A. Alves¹ ^, ² , Patrícia P. G. Chaves¹ , Luiz M. S. T. Santos¹ , Tanus J. Nagem² , Silvane M. F. Murta³ , Isabela P. Ceravolo³ , Alvaro J. Romanha³ , Carlos L. Zani¹

¹Lab. de Química de Produtos Naturais. Centro de Pesquisas “René Rachou”, FIOCRUZ, Cx. Postal 1743, CEP 30190.002, Belo Horizonte, MG Brazil
²Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG Brazil
³Lab. de Parasitologia Celular e Molecular, Centro de Pesquisas “René Rachou”, FIOCRUZ, Cx. Postal 1743, CEP 30190.002, Belo Horizonte, MG Brazil

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC⁵⁰ of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).