Characterization of the Hypoglycemic Effects of Trigonella foenum graecum Seed

Laiquat Ali; Abul Kalam Azed Khan; Zahid Hassan; Mohammed Mosihuzzaman; Nilufar Nahar; Tahmina Nasreen; Muhammad Nur-e-Alam; Begun Rokeya

doi:10.1055/s-2006-958100

Planta Med 1995; 61(4): 358-360
DOI: 10.1055/s-2006-958100

Letters

Characterization of the Hypoglycemic Effects of Trigonella foenum graecum Seed

Laiquat Ali¹ , Abul Kalam Azed Khan¹ , Zahid Hassan¹ , Mohammed Mosihuzzaman² , Nilufar Nahar² , Tahmina Nasreen² , Muhammad Nur-e-Alam¹ , Begun Rokeya¹

¹Research Division, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), 122 Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh
²Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

Abstract

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Abstract

The whole powder of Trigonella foenum graecum seeds and its extracts were tested for their hypoglycemic effect on normal and diabetic model rats. The powder, its methanol extract, and the residue remaining after methanol extraction had significant hypoglycemic effects when fed simultaneously with glucose. The water extract of the methanol extractive-free residue of the seed powder showed significant hypoglycemic activity at different prandial states. The Soluble Dietary Fibre (SDF) fraction showed no effect on the fasting blood glucose levels of nondiabetic or NIDDM model rats. However, when fed simultaneously with glucose, it showed a significant hypoglycemic effect (p < 0.05) in NIDDM model rats. Chemical analysis showed that the major constituent of the SDF is a galactomannan. The results confirm the involvement of SDF in the hypoglycemic effect of T. foenum graecum seeds. However, compound(s) other than SDF is (are) also involved in the hypoglycemic activity.

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