Efficient Total Synthesis of 5-Methoxypsoralen

Delphine Roux; Safwat Makki; Françoise Bévalot; Philippe Humbert

doi:10.1055/s-2006-958420

LETTER

Efficient Total Synthesis of 5-Methoxypsoralen

Delphine Roux*^a, Safwat Makki^b,c, Françoise Bévalot^a, Philippe Humbert^b
^a Laboratoire de Pharmacognosie, Faculté de Médecine et de Pharmacie, Place Saint Jacques, 25030 Besançon, France
Fax: +33(3)81665568; e-Mail: delphine.roux@edu.univ-fcomte.fr;
^b Laboratoire d’Ingénierie et de Biologie Cutanées, Faculté de Médecine et de Pharmacie, Place Saint Jacques, 25030 Besançon, France
^c Laboratoire de Pharmacie Galénique, Faculté de Médecine et de Pharmacie, Place Saint Jacques, 25030 Besançon, France

Abstract

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Abstract

A rapid and efficient synthesis of 5-methoxypsoralen, furocoumarin commonly used in dermatology for the treatment by PUVA therapy of skin diseases, is described using cheap and easily available starting materials. An alternative method to synthesize 7-(2-oxoethoxy)coumarin, the key step to generate the furan ring, is suggested.

Key words

furocoumarin - psoralen - medicinal chemistry - total synthesis - furan ring

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References

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