Anti-Emetic Principles of Poria cocos

Takaaki Tai; Yasuhiko Akita; Kaoru Kinoshita; Kiyotaka Koyama; Kunio Takahashi; Kazuo Watanabe

doi:10.1055/s-2006-959363

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Planta Med 1995; 61(6): 527-530
DOI: 10.1055/s-2006-959363

Papers

Anti-Emetic Principles of Poria cocos

Takaaki Tai¹ , Yasuhiko Akita² , Kaoru Kinoshita² , Kiyotaka Koyama² , Kunio Takahashi² , Kazuo Watanabe³

¹Central Research Laboratory Kotaro Pharmaceutical Co. Ltd., 47-3 Suga-cho, Takatsuki-shi, Osaka 569, Japan
²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, 1-22-1 Yato-cho, Tanashi-shi, Tokyo 188, Japan
³Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263, Japan

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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

The triterpenes isolated from P. cocos and their derivatives were examined for anti-emetic activity. Some of these triterpenes inhibited emetic action induced by oral administration of copper sulfate pentahydrate to leopard frog. The triterpenes having an exomethylene group at C-24 showed anti-emetic activity to frogs.

Key words

Anti-emetic activity - Poria cocos - Polyporaceae - triterpenes