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Planta Med 1994; 60(3): 218-221
DOI: 10.1055/s-2006-959462
Paper

© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Agents from Heterotheca inuloides

Isao Kubo1 , Hisae Muroi1 , Aya Kubo1 , Swapan K. Chaudhuri1 , Yolanda Sanchez1 , Tetsuya Ogura2
  • 1Division of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, U.S.A.
  • 2Departamento de Quimica, Universidad Autonoma de Guadalajara, Guadalajara, Mexico
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

By bioassay directed fractionation, four sesquiterpenoids 1 - 4 were isolated as antimicrobial agents from the dried flowers of Heterotheca inuloides, a Mexican medicinal plant locally known as “arnica”. 7-Hydroxy-3,4-dihydrocadalin (3) and 7-hydroxycadalin (4) exhibited potent antibacterial activity against Gram-positive bacteria with minimum inhibitory concentrations (MICs) ranging from 6.25 to 12.5 µg/ml. Notably, 7-hydroxy-3,4-dihydrocadalin showed bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum bactericidal concentration (MBC) of 12.5 µg/ml.

Key words

Heterotheca inuloides - Asteraceae - antimicrobial activity - bactericidal activity - sesquiterpenoids - 7-hydroxy-3,4-dihydrocadalin