Antinociceptive Mechanism of the Actonitine Alkaloids Mesaconitine and Benzoylmesaconine

Yasuyuki Suzuki; Tsutomu Oyama; Atsushi Ishige; Tomoko Isono; Akitoshi Asami; Yoshiki Ikeda; Masamichi Noguchi; Yuji Omiya

doi:10.1055/s-2006-959516

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Planta Med 1994; 60(5): 391-394
DOI: 10.1055/s-2006-959516

Paper

Antinociceptive Mechanism of the Actonitine Alkaloids Mesaconitine and Benzoylmesaconine

Yasuyuki Suzuki¹ , Tsutomu Oyama¹ , Atsushi Ishige² , Tomoko Isono¹ , Akitoshi Asami¹ , Yoshiki Ikeda¹ , Masamichi Noguchi¹ , Yuji Omiya¹

¹Pain Research Laboratory, Tsumura & Co., Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan
²Tsumura Central Research Laboratories, Tsumura & Co., Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan

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Publication History

1993

1994

Publication Date:
04 January 2007 (online)

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Abstract

We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.

Key words

Mesaconitine - benzoylmesaconine - Aconitum carmichaeli - Ranunculaceae - analgesia - brain stem