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Planta Med 1999; 65(2): 175-177
DOI: 10.1055/s-2006-960460
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© Georg Thieme Verlag Stuttgart · New York

Isobutylamides and a New Methylbutylamide from Piper sarmentosum

J. R. Stöhr1 , [3] , P.-G. Xiao2 , R. Bauer1
  • 1Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Düsseldorf, Germany
  • 2Institute of Medicinal Plant Development, Xi Bei Wang, Beijing, P.R. China
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

A homologous series of six 2E,4E-diene-isobutylamides and a new N-2′-methylbutyl-2E,4E-decadieneamide were isolated from the n-hexane extract of the aerial parts of Piper sarmentosum. While the crude extract was found to possess cyclooxygenase-1 (COX-1) and 5-lipoxygenase (5-LO) inhibitory activity (COX-1 IC50 = 19 µg/ml; 5-LO IC50 = 10 µg/ml), the isolated compounds showed only weak effects in both test systems.

3 This work is part of the PhD thesis of J. R. Stöhr