Effects of Thiol Compounds versus the Cytotoxicity of Valepotriates on Cultured Hepatoma Cells

C. Keochanthala-Bounthanh; M. Haag-Berrurier; J. P. Beck; R. Anton

doi:10.1055/s-2006-960923

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Planta Med 1990; 56(2): 190-192
DOI: 10.1055/s-2006-960923

Papers

Effects of Thiol Compounds versus the Cytotoxicity of Valepotriates on Cultured Hepatoma Cells

C. Keochanthala-Bounthanh¹ , M. Haag-Berrurier¹ , J. P. Beck² , R. Anton¹

¹Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Louis Pasteur, B.P. 24, F-67401 Illkirch Cédex, France
²Institut d'Hématologie et d'Immunologie, Université Louis Pasteur, 1 Place de l'Hôpital, F-67091 Strasbourg, France

Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

The antagonistic activity of various thiol compounds versus the cytotoxic effects of valtrate and didrovaltrate has been evaluated on cultured hepatoma cells. Compounds with free SH groups like cysteine, mercaptoethanol, dithioerythritol, and glutathione were able to suppress the cytotoxicity of the valepotriates in a dose-dependent way, whereas compounds with blocked SH groups did not antagonize these toxic effects. The possible interactions between the valepotriates and thiol compounds are discussed.

Key words

Valepotriates - cytotoxicity - hepatoma cells - thiol compounds antagonism