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Planta Med 1989; 55(2): 163-165
DOI: 10.1055/s-2006-961913
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© Georg Thieme Verlag Stuttgart · New York

Cytotoxicity of Isoquinoline Alkaloids and Their N-Oxides1

Yang-Chang Wu2 , Yei-Fei Liou3 , Sheng-Teh Lu4 , Chung-Hsiung Chen2 , Jer-Jang Chang5 , Kuo-Hsiung Lee2
  • 2Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.
  • 3Department of Microbiology, School of Medicine, Kaohsiung Medical College, Kaohsiung 80731, Taiwan, Republic of China
  • 4Department of Pharmacognosy, School of Pharmacy, Kaohsiung Medical College, Kaohsiung 80731, Taiwan, Republic of China
  • 5Division of Laboratory Animal Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.
1 Antitumor Agents: CIII. For paper CII in this series, see Lin, Y. M., Hung, J. C., Chen, F. C., Lee, K. H., Planta Med., in press
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1988

Publikationsdatum:
24. Januar 2007 (online)

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Abstract

A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.