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Planta Med 1989; 55(2): 166-168
DOI: 10.1055/s-2006-961914
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© Georg Thieme Verlag Stuttgart · New York

Hinokiflavone, a Cytotoxic Principle from Rhus succedanea and the Cytotoxicity of the Related Biflavonoids1

Yuh-Meei Lin2 , Fa-Ching Chen3 , Kuo-Hsiung Lee2
  • 2Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, U.S.A.
  • 3Chemistry Research Center, National Taiwan University and Tamkang University, P.O. Box 30373, Taipei 107, Taiwan
1 Antitumor Agents: CII. For paper CI in this series, see Wu, Y. C., Chen, C. H., Lu, S. T., Yang, T. H., McPhail, A. T., Lee, K. H., Phytochemistry, in press
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

Hinokiflavone (1) was isolated as the cytotoxic principle from the drupes of Rhus succedanea L. A comparison of the cytotoxicity of 1 and other related biflavonoids, including amentoflavone (2), robustaflavone (3), agathisflavone (4), rhusflavone (5), rhusflavanone (6) and its hexaacetate (7), succedaneaflavanone (8) and its hexaacetate (9), cupressuflavone (10), neorhusflavanone (11), volkensiflavone (12) and its hexamethyl ether (13), spicataside (14) and its nonaacetate (15), morelloflavone (16) and its heptaacetate (17) and heptamethyl ether (18), GB-1a (19) and its hexamethyl ether (20) and 7″-O-β-glucoside (21), and GB-2a (22), indicates that an ether linkage between two units of apigenin as seen in 1 is structurally required for significant cytotoxicity. Compounds 13 and 20 also demonstrated significant cytotoxicity.