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Planta Med 1987; 53(2): 201-206
DOI: 10.1055/s-2006-962672
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© Georg Thieme Verlag Stuttgart · New York

In Vitro Amoebicidal Testing of Natural Products; Part 2. Alkaloids Related to Emetine

Alison T. Keene1 , J. David Phillipson1 , David C. Warhurst2 , Michel Koch3 , Elisabeth Seguin3
  • 1Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, U.K.
  • 2Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, University of London, Gower Street, London, WC1, U.K.
  • 3Department de Pharmacognosie de l'Universite Rene Descartes Paris V, U.A. au C.N.R.S. No. 484, Faculte des Sciences Pharmaceutiques et Biologiques, 4 Ave de l'Observatoire, F-75006 Paris, France.
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1986

Publikationsdatum:
24. Januar 2007 (online)

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Abstract

A series of 18 alkaloids with structural similarities to emetine have been tested for their in vitro activity against Entamoeba histolytica (NIH 200) and guinea-pig ear keratinocytes. The alkaloids contain either two benzyltetrahydroisoquinoline, two tetrahydro-β-carboline, or mixed benzyltetrahydroisoquinoline/tetrahydro-β-carboline moieties and are of the emetine, tubulosine, and ochrolifuanine class of alkaloids. The results are discussed on the basis of structure-activity relationships.