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Semin Thromb Hemost 2007; 33(8): 759-770
DOI: 10.1055/s-2007-1000366
© Thieme Medical Publishers

Genomics and Proteomics in Venous Thromboembolism: Building a Bridge toward a Rational Personalized Medicine Framework

Giuseppe Lippi1 , Massimo Franchini2 , Martina Montagnana1 , Gian Cesare Guidi1
  • 1Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona, Italy
  • 2Servizio di Immunoematologia e Trasfusione - Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
Further Information

Publication History

Publication Date:
04 January 2008 (online)

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ABSTRACT

Venous thromboembolism is a major health care problem worldwide and is sustained by a multifactorial pathogenesis where both congenital and acquired causes contribute. It is increasingly being highlighted that a reliable approach based on genomics and proteomics might be effective to construct a rational personalized medicine framework that can be applied in the preclinical, clinical, and therapeutic settings of venous thrombosis. The aim of this review is to provide a concise description of the current and future applications of genomics and proteomics in this challenging pathology.

KEYWORDS

Diagnosis - genomics - proteomics - therapy - venous thromboembolism

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Prof. Giuseppe Lippi

Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Ospedale Policlinico G.B. Rossi, Piazzale Scuro

10, 37134 Verona, Italy

Email: giuseppe.lippi@univr.it; ulippi@tin.it