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Horm Metab Res 1992; 24(11): 516-519
DOI: 10.1055/s-2007-1003378
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Normal Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Activity in Plasma from Patients with Type 1 Diabetes Mellitus

A. M. Vicari, S. Viganó D'Angelo1 , S. Testa1 , G. Comi2 , G. Galardi2 , E. Orsi, A. D' Angelo1
  • Department of Medicine, IRCCS H. S. Raffaele, Milano, Italy
  • 1Coagulation Service, IRCCS H. S. Raffaele, Milano, Italy
  • 2Department of Neurology, IRCCS H. S. Raffaele, Milano, Italy
Further Information

Publication History

1991

1992

Publication Date:
14 March 2008 (online)

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Summary

The fibrinolytic system was investigated in 38 patients (21 males and 17 females) affected by type 1 diabetes mellitus (18 free from complications, 10 with retinopathy, and 10 with autonomic neuropathy) and in 8 healthy controls. Two separate fibrinolysis-stimulating tests were done: standardized venous occlusion and 1-desamino-8-D-arginine vasopressin infusion. Plasma tissue plasminogen activator antigen and activity and plasma plasminogen activator inhibitor activity were measured. All the patients were in good metabolic control (mean HbA1c 7.4%, range 6.1-8.0%). No significant differences were observed either between the diabetic patients and the control subjects, nor among the subgroups of diabetic patients. The fibrinolytic system is probably not involved in type 1 diabetes mellitus.

Key words

Type 1 Diabetes Mellitus - Plasminogen Activator - Plasminogen Activator Inhibitor - Fibrinolysis