Horm Metab Res 1987; 19(2): 80-83
DOI: 10.1055/s-2007-1011744
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Acute Changes in Plasma Renin Activity, Plasma Aldosterone Concentration and Plasma Electrolyte Concentrations Following Furosemide Administration in Patients with Congestive Heart Failure - Interrelationships and Diuretic Response

H. Mulder1 , W. Schopman1  Jr. , A. J. van der Lely1 , W. Schopman2  Sr. 
  • 1Department of Internal Medicine, Eudokia Hospital, Rotterdam, The Netherlands
  • 2Laboratory of Endocrinological Biochemistry, Bergweg Hospital, Rotterdam, The Netherlands
Further Information

Publication History

1985

1986

Publication Date:
24 April 2008 (online)

Summary

We studied the effects of furosemide on plasma renin and plasma aldosterone in 8 patients with mild to moderate congestive heart failure. In particular, we tried to correlate these effects with changes in plasma electrolyte concentrations and with the diuretic response on furosemide. We concluded that the diuretic response in patients with congestive heart failure is not dependent on the initial serum renin nor on the initial serum aldosterone concentration. The diuretic response did not correlate either with the changes in serum renin and/or serum aldosterone concentration. Serum renin and serum aldosterone correlated mutually before and after intravenous furosemide. We confirmed the inverse correlation between serum sodium and serum renin. SeNa and SeK correlated at all times with serum aldosterone; SeCl correlated with serum aldosterone only before intravenous furosemide administration. Indirect evidence could be provided that in patients with congestive heart failure a decreased renal blood flow is present, using the urinary β2-microglobulin concentration. Aldosterone has again, indirectly, proved to be integrated in the renal magnesium handling.