Facile Addition of Ketones to Activated Isoquinolines Using N-Methyl-2-pyrrolidinone

Abstract

Ketones undergo a smooth addition to N-acylisoquinolinium ions in N-methyl-2-pyrrolidinone, under mild conditions, to produce 1-alkylated isoquinoline derivatives in excellent yields with high regioselectivity. The use of commercially available N-methyl-2-pyrrolidinone makes this process quite simple, more convenient and practical.

Keywords

activated isoquinolines - ketones - 1-alkyl-1,2-dihydroquinolines

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