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Synthesis 2007(8): 1175-1178
DOI: 10.1055/s-2007-965979
DOI: 10.1055/s-2007-965979
PAPER
© Georg Thieme Verlag Stuttgart · New York
Stereoselective Synthesis of a Key Intermediate of (-)-Apicularen A
Further Information
Received
3 January 2007
Publication Date:
12 March 2007 (online)
Publication History
Publication Date:
12 March 2007 (online)
Abstract
Progress towards the stereoselective formal synthesis of (-)-apicularen A is described. The convergent approach involves the assembly of aliphatic and aromatic fragments via Grubbs’s cross metathesis. Other key reactions in the strategy include Sharpless asymmetric epoxidation, Evans’s protocol for the generation of syn 1,3-diol systems and stereoselective reduction.
Key Words
apicularen A - antitumor - Grubbs’s cross metathesis - Evans’s protocol
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