Mechanism of Antihepatotoxic Activity of Wuweizisu C and Gomisin A

Yoshinobu Kiso; Masahiro Tohkin; Hiroshi Hikino; Yukinobu Ikeya; Heihachiro Taguchi

doi:10.1055/s-2007-969504

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Planta Med 1985; 51(4): 331-334
DOI: 10.1055/s-2007-969504

Research Articles

Mechanism of Antihepatotoxic Activity of Wuweizisu C and Gomisin A[1]

Yoshinobu Kiso² , Masahiro Tohkin² , Hiroshi Hikino² , Yukinobu Ikeya³ , Heihachiro Taguchi³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
³Tsumura Laboratory, Komae, Tokyo, Japan

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Publication History

1985

1985

Publication Date:
26 February 2007 (online)

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Abstract

The mechanism of inhibitory action of wuweizisu C and gomisin A in carbon tetrachloride (CCl₄)-induced liver damage was investigated by determining the effects of these substances on the steps of the series of events leading to liver lesion.

Although wuweizisu C and gomisin A exerted no inhibition in CCl₃ radical formation, both lignans inhibited CCl₄-, ADP/Fe³⁺- and ascorbate/Fe²⁺-induced lipid peroxidation, and wuweizisu C elicited stronger effects than gomisin A which is parallel with the results on antihepatotoxic effects in CCl₄-induced cytotoxicity, indicating that anti-oxidative action plays an important part in the antihepatotoxic activity of wuweizisu C and gomisin A.

1 Part 28 in the Tohoku University series on Liver-protective drugs. Also Part 97 on the validity of the Oriental medicines