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Planta Med 1984; 50(3): 213-218
DOI: 10.1055/s-2007-969681
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Antihepatotoxic Actions of Lignoids from Schizandra chinensis Fruits[1]

Hiroshi Hikino2 , Yoshinobu Kiso2 , Heihachiro Taguchi3 , Yukinobu Ikeya3
  • 2Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
  • 3Tsumura Laboratory, Komae, Tokyo, Japan
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Publication Date:
26 February 2007 (online)

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Abstract

The antihepatotoxic effects of twenty-three lignans, twenty-two from the fruits of Schizandra chinensis and one from the fruits of Kadsura japonica, were investigated utilizing carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. Prominent protective actions were found with wuweizisu C and schisantherin D in CCl4-treated cultures, and deoxygomisin A, gomisin N, wuweizisu C, gomisin C and schisantherin D were effective in preventing GalN-induced cell damage. Structure-activity relationship suggests that the methylenedioxy group of the dibenzocyclooctane skeleton may play an important role in antihepatotoxic activity.

1 Part 11 in the Tohoku University series on Liver-protective drugs. Also Part 60 on the validity of the Oriental medicines.

1 Part 11 in the Tohoku University series on Liver-protective drugs. Also Part 60 on the validity of the Oriental medicines.