Inhibition of Monoamine Oxidase by Hypercin

O. Suzuki; Y. Katsumata; M. Oya; S. Bladt; H. Wagner

doi:10.1055/s-2007-969700

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Planta Med 1984; 50(3): 272-274
DOI: 10.1055/s-2007-969700

Reports

Inhibition of Monoamine Oxidase by Hypercin

O. Suzuki¹ , Y. Katsumata² , M. Oya² , S. Bladt³ , H. Wagner³

¹Department of Legal Medicine, 3600 Handa-cho Hamamatsu University School of Medicine, Hamamatsu 4-31-31, Japan
²Department of Legal Medicine, Nagoya University School of Medicine, Nagoya, Japan
³Institut für Pharmazeutische Biologie der Universität München, Karlstr. 29, D-8000 Müchen 2

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Publication Date:
26 February 2007 (online)

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Abstract

Hypericin from Hypericum perforatum was found to inhibit in vitro type A and B monoamine oxidase (MAO's) prepared by treating rat brain mitochondria with selective inhibitors. The inhibition of type A MAO by hypericin was higher than that of type B MAO. The inhibition was almost irreversible for both MAO types.