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Planta Med 1983; 49(12): 226-231
DOI: 10.1055/s-2007-969856
Research Articles

© Hippokrates Verlag Stuttgart

Helenalin- und 11,13-Dihydrohelenalinester aus Blüten von Arnica montana*

Helenalin- and 11,13-Dihydrohelenalinester from Flowers of Arnica montana G. Willuhn1 , P-M. Röttger1 , U. Matthiesen2
  • 1Institut für Pharmazeutische Biologie der Universität Düsseldorf
  • 2Institut für Physiologische Chemie II der Universität Düsseldorf, Bundesrepublik Deutschland
* Teilergebnisse der Dissertation P.-M. Röttoger, Düsseldorf 1981. Kurzvortrag, gehalten auf der Vortragstagung der Deutschen Pharmazeutischen Gesellschaft, Regensburg 1980, Pharm. Ztg. 125, 1803 (1980).
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1983

1983

Publication Date:
26 March 2007 (online)

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Abstract

From the flowers of Arnica montana L. 13 helenanolides were isolated and identified. They are shown to be 11,13-dihydrohelenalin (1), helenalin (2) and their ester derivatives 3-13 (see figure). The natural occurence of 6-O-isobutyryl-, 6-O-tigloyl-, 6-O-isovaleryl- and 6-O-(2-methyl)-butyrylhelenalin (compounds 9, 11, 12, 13) is reported for the first time. The qualitative sesquiterpene lactone composition in flowers of A. montana from different regions was found to be variable.

Key Word Index

Arnica montana L. - Asteraceae - Sesquiterpene lactones - Pseudoguaianolides, Helenanolides, Helenalin, 11,13-dihydrohelenalin and ester derivatives - GC/MS-analysis - MS-fragmentation