Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from Chelidonoum majus*,**

J. Lenfeld; M. Kroutil; E. Maršálek; J. Slavík; V. Preininger; V. Šimánek

doi:10.1055/s-2007-971493

Planta Medica, Inhaltsverzeichnis

Planta Med 1981; 43(10): 161-165
DOI: 10.1055/s-2007-971493

Research Articles

Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from *Chelidonoum majus,

J. Lenfeld¹ , M. Kroutil¹ , E. Maršálek² , J. Slavík³ , V. Preininger⁴ , V. Šimánek⁴

¹Institute of Pharmacology, Medical Faculty, Palacký University, Olomouc, ČSSR
²Institute of Microbiology, Medical Faculty, Palacký University, Olomouc, ČSSR
³Institute of Medical Chemistry and Biochemistry, Medical Faculty, J. Ev. Purkyně University, Brno, ČSSR
⁴Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc, ČSSR

* Part LXXXIV in the series: “Isolation, Chemistry and Biology of Alkaloids from Plants of the Papaveraceae”. For pan LXXXIII see ref. [10].** Dedicated to the 60th Birthday of Professor H. Oelschläger, Frankfurt am Main

Abstract

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Abstract

The fraction of quaternary benzophen-anthridine alkaloids from roots of Chelidonium majus L., containing chelerythrme and sanguinarme, has been tested for its antiinflammatory activity. On the basis of its low toxicity, high antiinflammatory activity and antimicrobial action, it is recommended for medical use in the treatment of oral inflammatory processes.

Key Word Index

Chelidonium majus - Papaveraceae - Sanguinarine, Chelerythrine - Antiinflammatory and Antimicrobial Activity - Toxicity

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