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Planta Med 1981; 43(10): 161-165
DOI: 10.1055/s-2007-971493
Research Articles

© Hippokrates Verlag Stuttgart

Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from Chelidonoum majus*,**

J. Lenfeld1 , M. Kroutil1 , E. Maršálek2 , J. Slavík3 , V. Preininger4 , V. Šimánek4
  • 1Institute of Pharmacology, Medical Faculty, Palacký University, Olomouc, ČSSR
  • 2Institute of Microbiology, Medical Faculty, Palacký University, Olomouc, ČSSR
  • 3Institute of Medical Chemistry and Biochemistry, Medical Faculty, J. Ev. Purkyně University, Brno, ČSSR
  • 4Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc, ČSSR
* Part LXXXIV in the series: “Isolation, Chemistry and Biology of Alkaloids from Plants of the Papaveraceae”. For pan LXXXIII see ref. [10].** Dedicated to the 60th Birthday of Professor H. Oelschläger, Frankfurt am Main
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Publication Date:
30 March 2007 (online)

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Abstract

The fraction of quaternary benzophen-anthridine alkaloids from roots of Chelidonium majus L., containing chelerythrme and sanguinarme, has been tested for its antiinflammatory activity. On the basis of its low toxicity, high antiinflammatory activity and antimicrobial action, it is recommended for medical use in the treatment of oral inflammatory processes.

Key Word Index

Chelidonium majus - Papaveraceae - Sanguinarine, Chelerythrine - Antiinflammatory and Antimicrobial Activity - Toxicity