Apoptosis in Brain Biopsies of Subacute Sclerosing Panencephalitis Patients

B. Anlar; F. Söylemezoǧlu; B. Elibol; T. Dalkara; S. Aysun; G. Köse; D. Belen; K. Yalaz

doi:10.1055/s-2007-973497

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000041.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Neuropediatrics 1999; 30(5): 239-242
DOI: 10.1055/s-2007-973497

Original articles

Apoptosis in Brain Biopsies of Subacute Sclerosing Panencephalitis Patients

B. Anlar¹ , F. Söylemezoǧlu² , B. Elibol⁵ , T. Dalkara⁵ , S. Aysun¹ , G. Köse³ , D. Belen⁴ , K. Yalaz¹

¹Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey
²Department of Pathology, Hacettepe University, Ankara, Turkey
³Department of Pediatric Neurology, SSK Ankara Hospital, Ankara, Turkey
⁴Department of Neurosurgery, SSK Ankara Hospital, Ankara, Turkey
⁵Department of Neurology, Hacettepe University, Ankara, Turkey

Further Information

Publication History

Publication Date:
12 March 2007 (online)

Also available at

PDF Download Permissions and Reprints

Abstract

Subacute sclerosing panencephalitis (SSPE) is associated with inflammatory infiltration, neuronal loss, and demyelination. The pathogenesis of these changes is unclear. We examined DNA fragmentation and Bcl-2 expression in brain biopsies of nineteen SSPE patients to investigate the role of apoptosis in tissue damage. DNA fragmentation was present in oligoden-droglia, and, in tissues with neuronal loss, in neurons. Reactive astrocytes had no DNA fragmentation, but strong Bcl-2 expression. These results suggest apoptosis as one of the mechanisms for oligodendroglial and neuronal death in SSPE.

Key words

Apoptosis - Subacute sclerosing panencephalitis - Measles