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Planta Med 2007; 73(10): 1101-1106
DOI: 10.1055/s-2007-981565
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antinociceptive and Anti-Inflammatory Steroidal Saponins from Dracaena ombet

Fatma A. Moharram1 , Siham M. El-Shenawy2
  • 1Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt
  • 2Pharmacology Department, National Research Centre, El-Behoose St., El-Dokki, Cairo, Egypt
Further Information

Publication History

Received: September 7, 2006 Revised: June 3, 2007

Accepted: June 7, 2007

Publication Date:
12 July 2007 (online)

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Abstract

Two new steroidal saponins, namely (25R)-5β-spirostan-3-β-ol 3-O-β-D-galactopyranosyl-(1″′→4′′)-O-β-D-galactopyranosyl-(1″→3′)-O-β-D-glucopyranoside (2), and (25R)-5β-spirostan-3-β-ol 3-O-β-D-galactopyranosyl-(1″′→4′′)-O-β-D-glucopyranosyl-(1″→3′)-O-β-D-glucopyranoside (3), together with six known constituents, have been isolated from the leaves of Dracaena ombet Kotschy & Peyr. (Dracaenaceae). The structures of the two saponins were established by chemical and physicochemical analyses, including FAB- and HR-ESI-MS and 2D NMR. The fraction rich in saponins showed significant analgesic and anti-inflammatory activities (at a high dose of 30 mg/kg b. w.) and non-significant antiulcer activities at the same doses.

Key words

Dracaena ombet - Dracaenaceae - smilagenin glycosides - sulphated triterpenoidal saponin - flavonoids - analgesic - anti-inflammatory - antiulcer

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Prof. Dr. Fatma A. Moharram

Pharmacognosy Department

Faculty of Pharmacy

Helwan University

Helwan

Egypt

Phone: +20-2-548-1261

Fax: +20-2-554-1601

Email: famoharram1@hotmail.com

    www.thieme-connect.de/ejournals/toc/plantamedica