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Semin Thromb Hemost 2007; 33(6): 610-616
DOI: 10.1055/s-2007-985758
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Transgenic Mouse Models of Venous Thrombosis: Fulfilling the Expectations?

Audrey C.A Cleuren1 , Bart J.M van Vlijmen1 , Pieter H. Reitsma1
  • 1Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
Further Information

Publication History

Publication Date:
04 September 2007 (online)

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ABSTRACT

During the last 15 years, transgenic mice have been generated that carry defective and/or mutant alleles of the natural anticoagulant pathways and display a spontaneous thrombotic phenotype. With the generation of these mouse lines, better opportunities became available for investigating both existing and novel risk factors for venous thrombosis. In addition, these models could serve as a tool for evaluating novel antithrombotic strategies. This review summarizes these mouse models and evaluates whether they have fulfilled the expectations.

KEYWORDS

Venous thrombosis - natural anticoagulants - knockout mouse - mouse models - factor V Leiden

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Pieter H Reitsma

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center

C9-023, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Email: p.h.reitsma@lumc.nl