Abstract
Objective: Transcription factor Neurogenin 3 (NGN3) is considered as a candidate gene for the development of type 2 diabetes. The aim of the current study was to investigate the relevance of NGN3 variants for the clinical spectrum of diabetes development and disease progressions.
Research Design and Methods: A total of 552 subjects with increased risk of type 2 diabetes were investigated. They underwent a 75 g OGTT with measurements of plasma glucose, insulin and proinsulin at fasting and at 30, 60, 90 and 120 minutes after the glucose challenge, repeated after 3 years. The NGN3 SNPs, Gly167Arg and Ser199Phe were genotyped.
Result: Patients with type 2 diabetes carrying the variant genotype at SNP199 presented with significantly higher proinsulin levels. Proinsulin level was also associated with progression of diabetes mellitus. There was a discrete association of the Ser199Phe variant with evolution of the disease status.
Conclusion: A genetic variation in NGN3 gene may be among the genetic determinants involved in the pathogenesis of diabetes.
Key words
Neurogenin 3
- proinsulin - progression of type 2 diabetes
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Correspondence
Dr. P.E.H. Schwarz
Medical Faculty Carl-Gustav-Carus of the Technical University Dresden
Medical Clinic III
Building 10
Room 108
Fetscherstrasse 74
01309 Dresden
Germany
Telefon: +49/351/458 27 15
Fax: +49/351/458 73 19
eMail: peter.schwarz@uniklinikum-dresden.de