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Endoscopy 2008; 40(1): 30-35
DOI: 10.1055/s-2007-995359
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Diagnostic yield of capsule endoscopy in ulcerative colitis and inflammatory bowel disease of unclassified type (IBDU)

S.  Mehdizadeh1 , 2 , G.  Chen3 , P.  J.  Enayati3 , D.  W.  Cheng3 , N.  J.  Han3 , O.  A.  Shaye3 , A.  Ippoliti1 , 4 , E.  A.  Vasiliauskas1 , 4 , S.  K.  Lo1 , 2 , K.  A.  Papadakis1 , 4
  • 1Division of Gastroenterology, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California, USA
  • 2Pancreaticobiliary and Interventional Endoscopy Program, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California, USA
  • 3Department of Medicine, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California, USA
  • 4Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California, USA
Further Information

Publication History

submitted 3 July 2007

accepted after revision 9 August 2007

Publication Date:
05 December 2007 (online)

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Commentaire de travail de S. Mehdizadeh et al., pp. 30Endoscopy 2008; 40(01): 89-90
DOI: 10.1055/s-0032-1306803

Background and study aims: Capsule endoscopy is increasingly reported as an important diagnostic procedure in patients with known or suspected Crohn’s disease, but its clinical utility in patients with ulcerative colitis or unclassified type inflammatory bowel disease (IBDU) is unclear. The aim of our study was to determine the diagnostic yield of capsule endoscopy for small-bowel disease in patients with ulcerative colitis and IBDU.

Patients and methods: All data from patients with a history of ulcerative colitis or IBDU who underwent capsule endoscopy between October 2001 and August 2005 were analyzed for procedure indications and findings. Images were reviewed by an experienced capsule endoscopist. The finding of multiple ulcerations (three or more) on capsule endoscopy was classified as diagnostic of small-bowel Crohn’s disease.

Results: 120 patients had undergone 122 capsule endoscopy procedures. Overall, 19 of 120 patients (15.8 %) had capsule endoscopy findings consistent with the diagnosis of Crohn’s disease. The proportion of patients with small-bowel disease was significantly higher among patients with a history of colectomy (7 of 21 patients, 33 %) compared with those without colectomy (12/99, 12 %) (P = 0.04). Among patients with positive findings on capsule endoscopy, 18 had also previously undergone a small-bowel follow-through study and only one showed findings consistent with Crohn’s disease.

Conclusions: Many patients with a diagnosis of ulcerative colitis and atypical features or IBDU may have small-bowel findings on capsule endoscopy that are consistent with Crohn’s disease. Capsule endoscopy should be considered in ulcerative colitis patients with atypical clinical features particularly after colectomy.

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K. A. Papadakis, MD, PhD

University of Crete
Faculty of Medicine, Department of Gastroenterology

University Hospital of Heraklion

PO Box 1352, Heraklion 71110,

Crete, Greece

Fax: +30-2810-542085

Email: Papadakis.konstantinos@gmail.com