One-Pot Synthesis of Pyrrolo[2,1-a]isoquinoline-1-carboxamide Derivatives via a Four-Component Reaction

Abstract

An effective route to functionalized 1,2,3,10b-tetrahydropyrrolo[2,1-a]isoquinoline-1-carboxamide derivatives is described. This involves reaction of N-alkyl-3-oxobutanamides, which result from the addition of amines to diketene, and dibenzoyl­acetylene in the presence of isoquinoline. The reactive 1:1 intermediate obtained from the addition of isoquinoline to diben­zoyl­-acetylene is trapped by OH acids such as N-alkyl-3-oxobutan­amides to produce the pyrrolo[2,1-a]isoquinoline-1-carboxamide derivatives.

Key words

amine - diketene - dibenzoylacetylene - isoquinoline - multicomponent reaction - pyrroloisoquinoline

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