Ultrasound-Enhanced Thrombolysis: EKOS EndoWave Infusion Catheter System

ABSTRACT

The purpose of the EKOS EndoWave Infusion Catheter System is to enhance catheter-directed thrombolysis by accelerating the fibrinolytic process with the application of ultrasound. Improving the efficiency of the thrombolytic process reduces the treatment time and total lytic dose delivered, thereby lowering the overall cost of therapy and the risk of an associated bleeding complication.

KEYWORDS

Thrombolysis - ultrasound - catheter - clot - interventional radiology

REFERENCES

• 1 Strandness D E, Langlois Y, Cramer M et al.. Long-term sequelae of acute venous thrombosis.  JAMA. 1983;  250 1289-1292
• 2 Meissner M H, Manzo R A, Bergelin R O et al.. Deep vein insufficiency: the relationship between lysis and subsequent reflux.  J Vasc Surg. 1993;  18 596-605
• 3 Diamond S L, Anand S. Inner clot diffusion and permeation during fibrinolysis.  Biophys J. 1993;  65 2622-2643
• 4 Francis C W, Blinc A, Lee S et al.. Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots.  Ultrasound Med Biol. 1995;  21 419-424
• 5 Francis C W. Ultrasound-enhanced thrombolysis.  Echocardiography. 2001;  18 239-246
• 6 Kudo S. Thrombolysis with ultrasound effect.  Tokyo Jikeikai Med J. 1989;  104 1005-1012
• 7 Francis C W, Onundarson P T, Carstensen E L et al.. Enhancement of fibrinolysis in vitro by ultrasound.  J Clin Invest. 1992;  90 2063-2068
• 8 Suchkova V, Siddiqi F N, Carstensen E L et al.. Enhancement of fibrinolysis with 40 kHz ultrasound.  Circulation. 1998;  98 1030-1035
• 9 Riggs P N, Francis C W, Bartos S R et al.. Ultrasound enhancement of rabbit femoral artery thrombolysis.  Cardiovasc Surg. 1997;  5 201-207
• 10 Luo H, Nishioka T, Fishbein M C et al.. Transcutaneous ultrasound augments lysis of arterial thrombi in vivo.  Circulation. 1996;  94 775-778
• 11 Tachibana K. Enhancement of fibrinolysis with ultrasound energy.  J Vasc Interv Radiol. 1992;  3 299-303
• 12 Tachibana K, Tachibana S. Prototype therapeutic ultrasound emitting catheter for accelerating thrombolysis.  J Ultrasound Med. 1997;  16 529-535
• 13 Shlansky-Goldberg R D, Cines D B, Sehgal C M. Catheter-delivered ultrasound potentiates in vitro thrombolysis.  J Vasc Interv Radiol. 1996;  7 313-320
• 14 Atar S, Luo H, Nagai T et al.. Arterial thrombus dissolution in vivo using a transducer-tipped, high-frequency ultrasound catheter and local low-dose urokinase delivery.  J Endovasc Ther. 2001;  8 282-290
• 15 Mahon B R, Nesbit G M, Barnwell S L et al.. North American clinical experience with the EKOS MicroLysUS infusion catheter for the treatment of embolic stroke.  AJNR Am J Neuroradiol. 2003;  24 534-538
• 16 McNamara T, Parikh S, Motarjeme A et al.. Ultrasound accelerated thrombolysis in peripheral arterial occlusion: complete lysis rates using the EKOS Lysus system in the same day setting. Presented at: Transcatheter Cardiovascular Therapeutics October 2005 Abstract 365
• 17 Wissgott C, Richter A, Kamusella P, Steinkamp H J. Treatment of critical limb ischemia using ultrasound-enhanced thrombolysis (PARES Trial): final results.  J Endovasc Ther. 2007;  14 438-443
• 18 Ouriel K, Veith F J, Sasahara A A. A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs.  N Engl J Med. 1998;  338 1105-1111
• 19 Raabe R A. Ultrasound-facilitated thrombolysis in treating DVT.  Endovascular Today. 2006;  5 75-79
• 20 Mewissen M W, Seabrook G R, Meissner M H et al.. Catheter-directed thrombolysis for lower extremity deep venous thrombosis: report of a national multicenter registry.  Radiology. 1999;  211 39-49
• 21 Motarjeme A. Ultrasound-enhanced thrombolysis.  J Endovasc Ther. 2007;  14 251-256