Semin Thromb Hemost 2008; 34(1): 026-032
DOI: 10.1055/s-2008-1066020
© Thieme Medical Publishers

Metabolic Modulation of Inflammation-Induced Activation of Coagulation

Marcel Levi1 , Max Nieuwdorp1 , Tom van der Poll2 , 3 , Erik Stroes1
  • 1Department of Vascular Medicine/Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
  • 2Laboratory of Experimental Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
  • 3Center for Infection and Immunology Amsterdam (CINIMA), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Further Information

Publication History

Publication Date:
07 April 2008 (online)

ABSTRACT

The bidirectional interaction between coagulation and inflammation, which is relevant in various disease states that are dominated by systemic inflammatory responses, such as severe infection or chronic vascular disease, is modulated by metabolic factors. Changes in lipoprotein metabolism affect the inflammation-induced activation of coagulation, which may have impact on downstream effects, including organ dysfunction and survival. Likewise, glucose and insulin seem to influence inflammation-induced effects on coagulation and fibrinolysis. Hyperglycemia affects inflammation-induced and tissue factor-driven activation of coagulation, whereas hyperinsulinemia modulates the fibrinolytic response. There are indications that this modulatory role of metabolic factors in inflammation and coagulation may also have an impact on clinical outcome in various disease states.

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Marcel LeviM.D. Ph.D. 

Department of Internal Medicine, Academic Medical Centre F-4, Meibergdreef 9

1105 AZ Amsterdam, The Netherlands

Email: m.m.levi@amc.uva.nl