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Semin Thromb Hemost 2008; 34(1): 039-057
DOI: 10.1055/s-2008-1066023
© Thieme Medical Publishers

Current and Future Prospects for Anticoagulant Therapy: Inhibitors of Factor Xa and Factor IIa

Job Harenberg1 , Martin Wehling1
  • 1Clinical Pharmacology Mannheim, Vascular Pharmacotherapy, Faculty of Medicine, University of Heidelberg, Mannheim, Germany
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Publication History

Publication Date:
07 April 2008 (online)

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ABSTRACT

Indirect systemic and direct oral factor Xa and direct oral factor IIa inhibitors with improved pharmacologic profiles compared with heparins and vitamin K antagonists are currently in clinical development. This overview focuses on the indirect antithrombin dependent pentasaccharide derivatives of idraparinux and on the most advanced oral direct inhibitors to factor Xa (rivaroxaban and apixaban) and IIa (dabigatran). Specifically, the results of dose-finding studies for the prevention of venous thromboembolism after elective orthopedic surgery, the results of dose-finding studies for treatment of acute venous thromboembolism including prolonged prophylaxis of recurrent events, and the designs of ongoing clinical trials are reviewed.

KEYWORDS

Thromboembolism - factor Xa inhibitor - factor IIa inhibitor - anticoagulants - clinical trial

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Job HarenbergM.D. 

Clinical Pharmacology Mannheim, Vascular Pharmacotherapy, Faculty of Medicine, University of Heidelberg

Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

Email: job.harenberg@med.ma.uni-heidelberg.de