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Synthesis 2008(8): 1283-1287
DOI: 10.1055/s-2008-1072517
DOI: 10.1055/s-2008-1072517
PAPER
© Georg Thieme Verlag Stuttgart · New York
Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates
Further Information
Received
9 January 2008
Publication Date:
18 March 2008 (online)
Publication History
Publication Date:
18 March 2008 (online)
Abstract
A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce α-oxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient, and practical.
Key words
thiocyanation - ketones - iron(III) chloride - catalysis - α-oxo thiocyanates
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