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Semin Thromb Hemost 2008; 34(2): 199-203
DOI: 10.1055/s-2008-1079261
© Thieme Medical Publishers

Chemotherapy-Induced Thrombosis: A Role for Microparticles and Tissue Factor?

Daniel Lechner1 , Ansgar Weltermann1
  • 1Department of Medicine I, Medical University of Vienna, Vienna, Austria
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Publication History

Publication Date:
21 July 2008 (online)

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ABSTRACT

Chemotherapy is an independent risk factor of thromboembolic events in cancer patients. Various pathogenetic mechanisms have been hypothesized in the past, but until now their individual contribution to the risk of thrombosis has been hardly investigated in clinical trials. In recent years, studies increasingly suggested an association between the prothrombotic state in cancer patients and circulating tissue factor–exposing microparticles. In this review, we discuss the roles of tissue factor and microparticles with regard to chemotherapy-induced hypercoagulability.

KEYWORDS

Cancer - chemotherapy - thrombosis - tissue factor - microparticles

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Ansgar WeltermannM.D. 

Department of Medicine I, Medical University of Vienna

Waehringer Guertel 18-20, A-1090 Vienna, Austria

Email: ansgar.weltermann@meduniwien.ac.at